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In the SELECT trial, adverse events leading to permanent discontinuation were reported in 16.6% of semaglutide-treated participants versus 8.2% in the placebo group, which shows that persistence remains a meaningful clinical and commercial issue even in closely monitored study populations
Additionally, lifestyle factors play a significant role: weight gain, reduced physical activity, poor dietary adherence, or increased stress can all contribute to worsening glycaemic control, making it appear as though Rybelsus is no longer working
Before we talk about that, lets take a step back and talk about some basics here
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Precision medicine in type 2 diabetes: using individualized prediction models to optimize selection of treatment
47 These molecules can inhibit the cytotoxicity of maternal natural killer cells, induce apoptosis of activated immune cells, and promote the differentiation of regulatory T cells, thereby protecting the fetus from maternal immune system attack
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